Sunday, October 21, 2007

Research shows monoclonal antibody effective in multiple sclerosis

Thursday, October 18, 2007; Posted: 07:43 AM

http://www.tradingmarkets.com/.site/news/Stock News/715117/
Oct 18, 2007 (Datamonitor via COMTEX) -- ACOR | charts | news | PowerRating -- Researchers at Mayo Clinic have presented details from a preclinical study showing that a recombinant human monoclonal antibody, administered in a single low dose in a laboratory mouse model of multiple sclerosis, can repair myelin, the insulating covering over nerve fibers in the central nervous system.

The antibody, which was genetically engineered for large-scale production, binds to myelin and the surface of cells in the brain and spinal cord, triggering the cells to begin the repair process called remyelination. The study was conducted using a laboratory mouse model of chronic progressive multiple sclerosis in humans. The antibody was delivered alone and in combination with the steroid methylprednisolone, remyelination was detected in both instances. The antibody is being developed by Mayo Clinic and Acorda Therapeutics.

Andrew Blight, chief scientific officer at Acorda, said: "We are excited to be collaborating with Mayo on the development of this therapy. The options for treatment of MS are still quite limited, and a new approach that could repair damage to the central nervous system would represent an important advance for the individuals who live with this disease."

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http://www.tradingmarkets.com/.site/news/Stock%20News/715117/

Research shows monoclonal antibody effective in multiple sclerosis
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Oct 18, 2007 (Datamonitor via COMTEX) -- ACOR | charts | news | PowerRating -- Researchers at Mayo Clinic have presented details from a preclinical study ...
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Treosulfan.com - The official site for treosulfan information

Why is this medication prescribed?

Treosulfan is one of a group of anti-cancer medicines called 'alkylating agents', which works by preventing the growth and division of cells and therefore stops them increasing in numbers.

This medication is commonly used as a chemotherapy drug to treat ovarian cancer. Doctors also sometimes use it in high doses to treat people with leukaemia who are going to have a donor bone marrow or stem cell transplant.

Additionally, treosulfan is currently used in clinical trials on patients who desire to try a new treatment approach
http://www.treosulfan.com/

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Insomnia drug falls short in clinical trial

MediciNova said its product MC-305 for the treatment of insomnia didn't achieve statistically significant results in a Phase 2 clinical trial involving 90 patients. The company said it would stop the insomnia trial but try to license the product for development in treating psychiatric disorders.

“As announced in June, we remain focused on advancing two core assets: MN-221 for the treatment of status asthmaticus, for which we recently announced positive Phase 2A data, and MN-166 for the treatment of multiple sclerosis, which also demonstrated positive clinical benefits in the first-year analysis of a two-year Phase 2 clinical trial,” CEO Yuichi Iwaki said.

Shares closed at $7.45 but dropped to $5.40 in after-hours trading.

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