Friday, October 19, 2007

Treosulfan Effective and Safe for Active Secondary Progressive Multiple Sclerosis: Presented at ECTRIMS

Treosulfan Effective and Safe for Active Secondary Progressive ...
DG News - USA
... University of Wuerzburg, Wuerzburg, Germany, and colleagues evaluated the safety and efficacy of treosulfan in patients with SPMS who have failed or do ...
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Transformation Of Treatment Paradigm To Improve Patient Compliance With Multiple Sclerosis Therapy
The multiple sclerosis (MS) market is undergoing a revolution with the imminent introduction of innovative therapies that will change the approach toward the treatment of the disease. This market evolution has not escaped the notice of pharmaceutical and biotechnology companies across various tiers, as they engage in a race to develop inventive and effective treatment options for MS.
18 Oct 2007

Scientists Show Monoclonal Antibody Leads To Repair Of Myelin Sheath In Laboratory Study Of Multiple Sclerosis
Researchers at Mayo Clinic have presented details from a preclinical study showing that a recombinant human monoclonal antibody, administered in a single low dose in a laboratory mouse model of multiple sclerosis, can repair myelin, the insulating covering over nerve fibers in the central nervous system.
18 Oct 2007


AUB tests stem-cell therapy on patients

By The Daily Star - Lebanon News - AUB tests stem-cell therapy on patients
Friday, October 19, 2007
AUB tests stem-cell therapy on patients

BEIRUT: Scientists at the American University of Beirut (AUB) began a pioneering clinical trial earlier this month to test bone-marrow stem-cell therapy on up to six individuals suffering from advanced Multiple Sclerosis (MS), a neurological disease with potentially debilitating effects.

The trial is among the first being carried out in the world, as part of an international task force created about a year ago, following successful animal trials
. AUB professor and neuroscientist Bassem Yamout, who is also a member of the European Charcot Foundation Expert Group on the use of human stem cells for treatment of Multiple Sclerosis, is leading the AUB trial which was launched on October 3. AUB assistant dean for research Ali Bazarbachi and his team will be collaborating with Yamout on this experiment.
"We think this is the future of treatment in neurology," said Yamout. "For the past 100 years, we have been trying to prevent or improve neurological diseases, but for the first time, we hope to repair the damage already done."
Through their animal trials, scientists have discovered that stem cells could potentially reverse the damage caused by neurological diseases. With the new clinical trials, researchers are now hoping to recreate the same results in human beings. Basically, each adult human body retains, in certain organs, original embryonic cells, known as stem cells, which have the potential to differentiate into any adult cell type.
In the multiple-sclerosis clinical trial, scientists at AUB extracted stem cells from an MS patient's bone marrow, grew them in the lab for four weeks, then re-injected 100 million of these stem cells in the patient's cerebrospinal fluid at two points: the lower back and neck. Since the cerebrospinal fluid bathes the spinal cord and brain (which constitute the central nervous system), the injected stem cells can reach areas damaged by the disease.
It is hoped that once those stem cells settle in the damaged parts of the central nervous system, they will differentiate into new neural cells, replacing dysfunctional ones, thus reversing any disability caused by the disease. Moreover, scientists also expect that these new neural cells will also secrete substances that will aid in repair.
"We are very hopeful about the results and I personally think that this experiment which is among the first in the world in MS patients will open up a whole new avenue of research in the field of MS therapeutics," said Yamout, following the one-hour operation in which the AUB human trial was initiated in a 36-year-old male who has been suffering from multiple sclerosis since 1996 and has been wheelchair-bound since early 2006. "The patient did very well with no complications and was discharged the following day," Yamout added.
Patients participating in the trial will be monitored over a 12-month period, allowing scientists to detect any improvement.
If successful, this trial would have tremendous applications in other neurological diseases, such as Alzheimer's, stroke, Parkinson's and physical trauma to the spinal cord. In other words, people like Christopher Reeves, known to many as Superman, would have had the chance to be cured of his complete paralysis following his equestrian accident.
Up until now, very few MS patients around the world have been injected with stem cells. The AUB team, which helped set up the protocol needed for the human trials, is initiating one of the first scientifically based stem-cell therapeutic trials involving MS patients in the world. - The Daily StarThe image “file:///C:/Documents%20and%20Settings/Bill/My%20Documents/jokes/george%20bush%20videos/20071019012530.3-aub20071019012530.3-aub.jpg” cannot be displayed, because it contains errors.

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AUB tests stem-cell therapy on patients
Daily Star - Lebanon - Beirut,Lebanon
In the multiple-sclerosis clinical trial, scientists at AUB extracted stem cells from an MS patient's bone marrow, grew them in the lab for four weeks, ...
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NeoStem Spotlights Projected Multibillion-Dollar Adult Stem Cell ...
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The drug candidate originates in 4SC AG's own research pipeline. In prior pre-clinical and clinical studies, an outstanding potency and favourable ...
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Elan, Biogen get FDA extension of regulatory review for Tysabri to ... - USA
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Elan outlines Tysabri options, appoints advisers
MarketWatch - USA
Elan holds a 50% interest in Tysabri, a newer type of multiple sclerosis treatment which works by preventing immune cells from crossing blood vessel walls ...
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Elan appoints advisers over Tysabri deal
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Elan and Biogen are joint stakeholders in the multiple sclerosis treatment Tysabri. In a statement released this morning Elan said that in the event of ...
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Carl Icahn raises the stakes for Big Pharma - USA
The first, Tysabri, carries the most risk. There have been concerns that the multiple sclerosis treatment causes a life-threatening neurological disorder ...
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Biogen Idec in process of signing confidentiality agreement with ...
Financial Times - London,England,UK
And as a result, he said it would be relatively easy to switch over to Avonex and Tysabri. "That would be the side of the acquisition that would make a ...
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FDA to extend review of Biogen's Tysabri Mass High Tech: The ... - Charlotte,NC,USA
Cambridge-based Biogen Idec Inc. has suffered a temporary setback in its goal to have 100000 patients taking Tysabri in the coming years. ...
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Elan, Biogen say FDA will extend review period for Tysabri
MarketWatch - USA
By Geoffrey Rogow , , ) on Monday said the Food and Drug Administration informed the companies that the agency will extend the regulatory review of Tysabri ...
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FDA Extends Tysabri Review - USA
Tysabri is already approved for relapsing forms of multiple sclerosis in the US and relapsing-remitting MS in the EU Because two patients died in clinical ...
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Elan says has Tysabri options - USA
NEW YORK (AP) - Elan Corporation Plc. (NYSE:ELN) said Monday it has several options for its share in the multiple sclerosis drug Tysabri if partner Biogen ...
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Genzyme's Campath Effective in MS - USA
NEW YORK (Associated Press) - Biotechnology company Genzyme Corp. said Monday its leukemia drug Campath was more effective than Merck KGaA's Rebif in ...
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Genzyme Shows Off a Drug Candidate
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Alemtuzumab, trade name Campath, has been approved in the US since 2001 to treat a form of leukemia. In the phase 2 study, alemtuzumab was successful in ...
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NJ voters to decide spending $450M on stem cell work
Newsday - Long Island,NY,USA
... multiple sclerosis. If approved by voters, the borrowing would make New Jersey second only to California in public money devoted to stem cell research. ...
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Under the microscope
The Age - Melbourne,Victoria,Australia
Lacham-Kaplan is excited about the possibilities of stem-cell research - that it might cure diseases such as diabetes, Parkinson's and multiple sclerosis ...
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