Summaries of all the latest research findings on MS selected by a team based at the Institute of Neurology, London.
Multiple sclerosis - novel insights and new therapeutic strategies
This review focuses on novel aspects of the pathogenesis and advances in the therapy of multiple sclerosis (MS).
authors: Kieseier BC, Hemmer B, Hartung HP.
source: Curr Opin Neurol. 2005 Jun;18(3):211-20.
The authors clarify the mechanism of activation of astrocytes infected in a rat model. This mechanism is important in the pathogenesis of viral encephalitis, an animal model of multiple sclerosis.
authors: Carpentier PA, Williams BR, Miller SD
source: Glia. 2007 Feb;55(3):239-52.
This study finds a correlation between high circulating levels of vitamin D and a reduced risk of multiple sclerosis.
authors: Munger KL, Levin LI, Hollis BW, Howard NS, Ascherio A.
source: JAMA. 2006 Dec 20;296(23):2832-8
The authors studied the role of sex steroid hormones during pregnancy in multiple sclerosis, evaluating their effect on autoimmune response modulation. No links have been found between pregnancy-related immune suppression in multiple sclerosis patients and the CD95/CD95L system, which is involved in auto-destruction of T cells.
authors: Ehrlich S, Haas J, Zipp F, Infante-Duarte C.
source: J Neurol Sci. 2007 Jan;252(1):83-7. Epub 2006 Dec 12.
The authors explored depressive symptoms in a Swedish sample of multiple sclerosis patients, finding an association between depression, worse self-reported functioning and poorer sense of coherence.
authors: Gottberg K, Einarsson U, Fredrikson S, von Koch L, Holmqvist LW.
source: J Neurol Neurosurg Psychiatry. 2007 Jan;78(1):60-5. Epub 2006 Jul 17.
MS News
Summaries of MS news from websites around the world.
source: US National MS Society
A study supported in part by the US National MS Society compared levels of vitamin D in blood serum stored from military personnel during their service, and found that those with higher levels of vitamin D were at lower risk for later developing multiple sclerosis.
source: US National MS Society
The US Food and Drug Administration has issued a Public Health Advisory after receiving reports of the deaths of two individuals who were given the immune-suppressing drug Rituxan® (rituximab, Genentech and Biogen Idec) to treat systemic lupus erythematosus.
source: UK MS Society
The UK MS Society is seeking the views of people affected by MS about the information they need and want.
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