Thursday, August 14, 2008

MS Answers - High-dose cyclophosphamide shows promise for aggressive multiple sclerosis

Daily Living with MS

Dr. Devonshire

Director of the University of British Columbia MS Clinic
View BIO


Q :
Recent research has shown that Vitamin D in high doses may help those with MS. It was recommended that 4000 I.Us be taken daily. Should the whole dosage be taken at once in the morning, or spaced out during the day?

A :

There are studies showing that many people with MS have low levels of vitamin D. There is also a possible association with low levels of sunlight (and therefore vitamin D) with the development of MS in populations. Support for this include the increased incidence of MS the further from the equator (the North-south gradient). There is no clinical or scientific evidence that supplementing with vitamin D helps MS. However, because vitamin D is involved in aspects of the immune system, and because in Canada our UV exposure is low, it makes sense to get these levels up. The Health Canada guidelines of 800 units per day are low and will likely be revised. However, there is no recommended dose. The University of Toronto recently reported their results on using doses of vitamin D supplementation at levels above 4000 units/day and found no real toxicity, at least in the short term. The University of Calgary had previously found that on average it takes about 2000 units to get most people with MS out of their D deficiency. Thus, most clinicians working in the area of MS are recommending 2000 units per day. Probably 4000 units is as high as one should go unless levels are to be checked. It can be taken as a full once per day dose, or can be divided. Many people will experience nausea at doses above 2000, and if this is the case, dividing the dose is suggested. But before you make any decision please discuss this with your family doctor.
8/14/2008 1:39:51 PM

More answers from Dr. Virginia Devonshire
More answers in the category: Daily Living with MS

 

DISCLAIMER: Please be aware that this information does not necessarily represent the opinion of the MS Society of Canada, and is not intended as medical advice. For specific advice and opinion, always consult a physician.
© 2008 Multiple Sclerosis Society of Canada | www.mssociety.ca

http://www.msanswers.ca/QuestionView.aspx?L=2&QID=2048



High-dose cyclophosphamide shows promise for aggressive multiple ...
Medicexchange - London,UK
High-dose cyclophosphamide, aimed at immune system ablation, is a safe and well-tolerated treatment for aggressive multiple sclerosis that can markedly ...
See all stories on this topic


MS drug may work against viral infection - US study
Reuters India - Mumbai,India
Low doses of the drug FTY720, also called fingolimod, given to mice once a day for three days eliminated an infection by a virus that can cause meningitis, ...
See all stories on this topic

 

Tovaxin Phase IIb clinical study TERMS

Opexa raises $3M in private placement
Bizjournals.com - Charlotte,NC,USA
The Woodlands-based Opexa (NASDAQ:OPXA) plans to present data from a Phase IIb clinical trial of Tovaxin in September. New institutional investors Lehman ...
See all stories on this topic

Opexa Completes Financing for Clinical Development of Tovaxin®
Woodlands Online, LLC - The Woodlands,TX,USA
Data from the company’s Tovaxin Phase IIb clinical trial (TERMS) are expected to be presented in September. New institutional investors Lehman Brothers and ...
See all stories on this topic

EMEA Assessing Tysabri PML Cases
The European Medicines Agency (EMEA) reports it is reviewing two cases progressive multifocal leukoencephalopathy (PML) in MS patients using Tysabri. The agency said it will determine whether any changes to the currently approved product information. Earlier this month Tysabri makers Ireland's Elan and its U.S. partner Biogen Idec revealed two new PML cases.


From Therapeutics Daily Archives:
Elan Dives As Double Whammy Rocks Company

 

Montel Williams multiple sclerosis

Montel Williams 'plugs' chiropractic
Chiropractic Economics - Ponte Vedra Beach,FL,USA
has been diagnosed with multiple sclerosis, which has caused him to suffer from pain, 24 hours a day. He said he experienced almost instantaneous relief ...
See all stories on this topic

• MS body suit
WHOI - Peoria,IL,USA
By Jen Christensen Multiple sclerosis (MS) is the name for a condition which affects communication within the central nervous system. ...
See all stories on this topic

 

 

Study: Physicians to Devote More Time to Online Sources
According to a new study, physicians report they will shift a significant amount of time currently devoted to offline professional sources to their online counterparts in the coming years. Currently, physicians conduct 41 percent of their pharmaceutical research online, but expect to increase that percentage to over 50 percent in the near future, the study said.

A disease cell line library

Researchers have created 20 disease-specific pluripotent cell lines from skin and bone marrow cells of patients with genetic disorders
By Andrea Gawrylewski

Some People Taking Cholesterol-fighting Statins Splitting Pills, Saving Money
From Canadian Press - Aug 12, 2008
TORONTO--A small but growing percentage of British Columbians who take statins to lower their cholesterol have twigged to the fact that they can save on their medication bills by pill splitting, a new study suggests. The study, which looked at statin prescriptions filled in B.C. over an 11-year period, was published Tuesday in the journal Open Medicine.


Probiotics

Expert discusses probiotics for specific health concerns
SmartBrief - Washington,DC,USA
Different probiotic strains target different body systems and health issues, from regulating digestion to warding off colds, according to microbiologist Dr. ...
See all stories on this topic

Take yoghurt to prevent ulcer, boost immunity
Nigerian Tribune - Ibadan,Nigeria
The study that looked at the effect of probiotics in athletes, said probiotic foods such as yoghurt, had a beneficial effect in treating people with ...
See all stories on this topic

 

As Boomers Age, Progress on Alzheimer's Front
After decades of arduous work, drug makers and academic researchers believe they've made considerable progress in bringing a new generation of treatments to market that may ease symptoms of the devastating brain disease and might even stop its progression. Eli Lilly, Baxter International and Medivation all have candidates in Phase III clinical testing. Wyeth along with partner Elan has said it still plans to persevere with Phase III trials for its candidate, despite some high-profile setbacks. GlaxoSmithKline and partner Epix Pharmaceuticals are in Phase II testing with their drug candidate, as is Australian-based Prana Biotechnology.

Green Tea Lowers Cholesterol
Stop Aging Now - Washington,DC,USA
Adiponectin is a hormone produced by fat cells that promotes sensitivity to insulin. Ghrelin is a hormone that relays messages between the digestive system ...
See all stories on this topic

 

 

Vitamin D

Get your sunny side up
Edmonton Sun - Alberta, Canada
Eggs are an excellent source of high-quality protein, plus they provide many vitamins and minerals, including vitamin B12, riboflavin, vitamin D, ...
See all stories on this topic

Whole in ones
Naperville Sun - naperville,IL,USA
... or can be cooked - are a great source of vitamin A. The bulbous part that grows underground brings lots of vitamin C. • Broccoli - Vitamins A and D are ...
See all stories on this topic

Suffering >From Chronic Pain? Try “Sunshine” Vitamin!
TheMedGuru - Chandigarh,India
by Neelam Goswami High intake of Vitamin D can reduce chronic pain in women, a new study has suggested. A team of researchers from the Institute of Child ...
See all stories on this topic

Low Levels Of Vitamin D Linked To Chronic Pain In Women
AHN - USA
London, England (AHN) - Low levels of Vitamin D may contribute to chronic pain among women and taking an extra daily dose of the sunshine vitamin may prove ...
See all stories on this topic

Vitamin D: A-Ray of Health Benefits
Natural Products Marketplace - Phoenix,Arizona,USA
BETHESDA, Md.—An in-depth review of current research on the health effects of vitamin D is being published as the proceedings of the late 2007 conference ...
See all stories on this topic

Fatty Acid and Vitamin D Status in the EPIC Trials of Crohn ...
Journal of American Medical Association (subscription) - Chicago,IL,USA
Second, no measurements were made of the vitamin D status in this population. This is unfortunate given the extremely high prevalence of vitamin D ...
See all stories on this topic

Fatty Acid and Vitamin D Status in the EPIC Trials of Crohn ...
Journal of American Medical Association (subscription) - Chicago,IL,USA
In Reply: Dr Plotnikoff alludes to the importance of the baseline omega-3/omega-6 ratio and vitamin D status as potential confounders. ...
See all stories on this topic

Vitamin D May Equal Longer Life
Associated Content - Denver,CO,USA
By Brad Sylvester, published Aug 12, 2008 Since my last article on the subject of vitamin D, there is even more evidence suggesting that maintaining good ...
See all stories on this topic

Low Level of Vitamin D Ups Death Risk
WebMD - USA
11, 2008 -- Very low levels of vitamin D are linked to increased risk of death, according to a new study. Michal Melamed, MD, MHS, of Albert Einstein ...
See all stories on this topic

Key Gaps Remain in Understanding Health Effects of Vitamin D
National Institutes of Health (press release) - USA
Despite considerable progress in research to understand the health effects of vitamin D, experts convened by the NIH to review the available data found ...
See all stories on this topic


 

 

 

Suit says kickbacks paid to PA doctors

    By Anne Zieger    
A Monroeville, PA-based medical supply company has filed suit against a handful of the industry's largest players, contending that the bigger players made kickback payments to local doctors to encourage use of their products. The suit, by Intermedics-McCullough, names Zimmer Inc. and Zimmer Holdings Inc., DuPuy Orthopedics, Biomet Inc., Smith and Nephew Inc., Stryker Orthopedics and Stryker Inc. The suit also names more than two dozen Pittsburgh-area physicians, along with a listing of payments the big device firms supposedly made to them. According to the Intermedics suit, the physicians received payments ranging from less than $100 to more than $8 million.
Intermedics-McCullough, which sold replacement hip joints, knee and shoulder implants and other orthopedic and surgical products, was an independent contractor for Sulzer-Medica Inc., which sold exclusively for the firm in western Pennsylvania and West Virginia. However, Intermedics asserts that between 1988 and 2007, the defendants crowded it out of the market with inferior and more-costly products by paying kickbacks.

The Intermedics suit follows on a federal investigation of the six companies named, which are estimated to account for 95 percent of the hip and knee surgical implant market. A criminal complaint in the New Jersey-based investigation held that the firms set up consulting agreements with orthopedics surgeons as a means of inducing them to specify the companies' products. The companies (other than Stryker Orthopedics, which cooperated with authorities) reached agreements late last year with the U.S. attorneys' office to avoid criminal prosecution. They agreed to pay $311 million in fines, as well having their payments to providers monitored.
To learn more about the suit:
- read this Pittsburgh Post-Gazette article

Related Articles:
Orthopedic surgeons receiving kickbacks?
Smith and Nephew settles kickback charges
Senate questions devicemaker payments to surgeons
Uncertainty strikes orthopedic device sector

Read more about: Criminal Prosecution, Stryker Orthopedics, DuPuy Orthopedics, Intermedics-McCullough


 

Neanderthals, modern humans share ancestor, scientists say

By Karen Kaplan

Researchers find a DNA link between the two species. >>

 

Runners Live Longer and Have Fewer Disabilities 
PALO ALTO, Calif. -- Regular running in middle age and beyond may lengthen lifespans and retard the disabilities of aging, a longitudinal study showed. full story

http://www.medpagetoday.com/PrimaryCare/ExerciseFitness/tb/10506

 

 

 

 

The image “http://z.about.com/d/hp/logo.gif” cannot be displayed, because it contains errors.
Diabetes

Debra Manzella, R.N.

By Debra Manzella, R.N.
Diabetes Guide

In the Spotlight | More Topics |

from Debra Manzella, R.N.
There's more than one reason to eat your broccoli. The newest research shows that a compound in this healthy green vegetable can guard against vascular disease in people with diabetes.


Tom Simonite, online technology editor

 

Rise Of The Rat-Brained Robots 

The electrical impulses from thousands of disembodied rat brain cells have been used to direct a wheeled robot around a laboratory. A sensor on the robot sends signals to the cultured rat neurons, whose responses can be used to make the robot react to its environment. The UK neuroscientists behind the research hope it will provide new insights into how the brain works...MORE

0 Comments:

Post a Comment

Links to this post:

Create a Link

<< Home