THE CHANGING VIEW OF MS
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OR
http://tinyurl.com/np4wb
NeuroInflammation Training Program: Members
Name: Amit Bar-Or, MD, FRCP(C)
Title: Assistant Professor
Institution: McGill University
Address: 3801 University Street
Phone: (514) 398-5132
Fax: (514) 398-7371
Email: amit.bar-or@mcgill.ca
Website: http://www.mni.mcgill.ca/neuroimu.html
Research Profile:
Dr. Amit Bar-Or directs a cellular and molecular immunology lab studying mechanisms of autoimmune disease with a
focus on multiple sclerosis (MS). His research is directed at understanding basic principles of immune regulation and
immune-neural interactions.
Area of Expertise:
Of particular interest are studies of B cell, antigen presenting cell, and T cell responses and their involvement in
central nervous system inflammation. Studies of the immature immune system in the context of early onset
(pediatric) MS, and reconstitution following immune ablation, are also being pursued, as are studies of immuneneural
interaction. Dr. Bar-Or has established a program in ‘Experimental Therapeutics’, which aims to develop and
incorporate novel immune assays into well-designed clinical trials of MS. This approach provides a unique
opportunity to gain insights into disease mechanisms and to develop biomarkers of response to therapy while also
evaluating the safety and efficacy of novel therapies in clinically well-characterized patients with MS.
Recent Publications:
1. Anderson DE, Bieganowska K, Bar-Or A, Oliveira EML, Hafler DA. Paradoxical inhibition of T cell function in
response to CTLA-4 blockade: heterogeneity within the human T cell repertoire. Nat Med 6:211-214, 2000.
2. Kipp B, Bar-Or A, Gausling G, Oliveira EM, Fruhan SA, Stuart DH, Hafler DA. A novel population of B7-1+ T cells
producing intracellular IL-4 is decreased in patients with multiple sclerosis. Eur.J.Immunol. 30:2092-2100, 2000.
3. Bar-Or A*, Oliveira EML, Anderson DE, Krieger JI, Duddy M, O'Connor KC, Hafler DA. Immunological Memory:
Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State. J Immunol
167(10):5669-5677, 2001.
4. Kim HJ, Antel JP, Duquette P, Alleva D, Conlon PJ, Bar-Or A*. Persistence of immune responses to altered and
native myelin antigens in patients with Multiple Sclerosis treated with altered peptide ligand. Clin Immunol
104(2):105, 2002.
5. Oliveira EML‡, Bar-Or A*‡, Waliszewska AI, Cai G, Anderson DE, Krieger JI, Hafler DA. CTLA-4 dysregulation in
the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy
controls. J Autoimmun 20:71-81. 2003. ‡Co-first authors.
6. Seguin R, Biernacki K, Prat A,Wosik K, Kim, H-J, Blain M, McCrea E, Bar-Or A, Antel JP. Differential effects of
Th1/Th2 lymphocyte supernatants on human microglia. Glia 42(1):36-45, 2003.
7. O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. Myelin basic
protein-reactive autoantibodies in the serum and CSF of multiple sclerosis patients are characterized by lowaffinity
interactions. J Neuroimmunol 136(1-2):140-148, 2003.
8. Alter A, Duddy M, Hebert S, Biernacki K, Prat A, Antel JP, Yong VW, Nuttall RK, Pennington CJ, Edwards DR, Bar-
Or A*. Determinants of human B cell migration across brain endothelial cells. J Immunol 170(9):4497-4505, 2003.
9. Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL.
Increased T cell reactivity to amyloid-beta protein in older humans and patients with Alzheimer disease. J Clin
Invest 112(3):415-422, 2003.
10. Antel JP and Bar-Or A. Do myelin antibodies predict the diagnosis of multiple sclerosis? NEJM. 349(2):107-
109;2003.
11. Bar-Or A‡, Nuttall RK‡, Duddy M, Alter A, Kim HJ, Ifergan I, Pennington CJ, Bourgoin P, Edwards DR,Yong VW.
Analyses of all matrix metalloproteinase members in leuckocytes: monocytes as major inflammatory mediators in
Multiple Sclerosis. ‡Co-first authors Brain 126: 2738-2749, 2003.
12. Duddy ME, Alter A, Bar-Or A*. Distinct profiles of human B cell effector cytokines: A role in immune regulation?
J Immunol. 172(6):3422-7, 2004.
13. Kim HJ, Biernacki K, Prat A, Antel JP, Bar-Or A*. Effects of glatiramer acetate-reactive T cells from patients with
multiple sclerosis on human Brain Endothelial Cells: Efficient migration without enhanced inflammation. Clin
Immunol, 111:35-46;2004.
14. Kim HJ, Ifergan I, Antel JP, Seguin R, Duddy M, Lapierre Y, Jalili F, Bar-Or A*. Type-2 monocyte and microglia
differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis. J Immunol. 172: 7144-
7153, 2004.
http://www.neuroinflammation.com/members.asp
http://www.mscare.org/cmsc/MS-Presentations.html
OR
http://tinyurl.com/np4wb
NeuroInflammation Training Program: Members
Name: Amit Bar-Or, MD, FRCP(C)
Title: Assistant Professor
Institution: McGill University
Address: 3801 University Street
Phone: (514) 398-5132
Fax: (514) 398-7371
Email: amit.bar-or@mcgill.ca
Website: http://www.mni.mcgill.ca/neuroimu.html
Research Profile:
Dr. Amit Bar-Or directs a cellular and molecular immunology lab studying mechanisms of autoimmune disease with a
focus on multiple sclerosis (MS). His research is directed at understanding basic principles of immune regulation and
immune-neural interactions.
Area of Expertise:
Of particular interest are studies of B cell, antigen presenting cell, and T cell responses and their involvement in
central nervous system inflammation. Studies of the immature immune system in the context of early onset
(pediatric) MS, and reconstitution following immune ablation, are also being pursued, as are studies of immuneneural
interaction. Dr. Bar-Or has established a program in ‘Experimental Therapeutics’, which aims to develop and
incorporate novel immune assays into well-designed clinical trials of MS. This approach provides a unique
opportunity to gain insights into disease mechanisms and to develop biomarkers of response to therapy while also
evaluating the safety and efficacy of novel therapies in clinically well-characterized patients with MS.
Recent Publications:
1. Anderson DE, Bieganowska K, Bar-Or A, Oliveira EML, Hafler DA. Paradoxical inhibition of T cell function in
response to CTLA-4 blockade: heterogeneity within the human T cell repertoire. Nat Med 6:211-214, 2000.
2. Kipp B, Bar-Or A, Gausling G, Oliveira EM, Fruhan SA, Stuart DH, Hafler DA. A novel population of B7-1+ T cells
producing intracellular IL-4 is decreased in patients with multiple sclerosis. Eur.J.Immunol. 30:2092-2100, 2000.
3. Bar-Or A*, Oliveira EML, Anderson DE, Krieger JI, Duddy M, O'Connor KC, Hafler DA. Immunological Memory:
Contribution of Memory B Cells Expressing Costimulatory Molecules in the Resting State. J Immunol
167(10):5669-5677, 2001.
4. Kim HJ, Antel JP, Duquette P, Alleva D, Conlon PJ, Bar-Or A*. Persistence of immune responses to altered and
native myelin antigens in patients with Multiple Sclerosis treated with altered peptide ligand. Clin Immunol
104(2):105, 2002.
5. Oliveira EML‡, Bar-Or A*‡, Waliszewska AI, Cai G, Anderson DE, Krieger JI, Hafler DA. CTLA-4 dysregulation in
the activation of myelin basic protein reactive T cells may distinguish patients with multiple sclerosis from healthy
controls. J Autoimmun 20:71-81. 2003. ‡Co-first authors.
6. Seguin R, Biernacki K, Prat A,Wosik K, Kim, H-J, Blain M, McCrea E, Bar-Or A, Antel JP. Differential effects of
Th1/Th2 lymphocyte supernatants on human microglia. Glia 42(1):36-45, 2003.
7. O'Connor KC, Chitnis T, Griffin DE, Piyasirisilp S, Bar-Or A, Khoury S, Wucherpfennig KW, Hafler DA. Myelin basic
protein-reactive autoantibodies in the serum and CSF of multiple sclerosis patients are characterized by lowaffinity
interactions. J Neuroimmunol 136(1-2):140-148, 2003.
8. Alter A, Duddy M, Hebert S, Biernacki K, Prat A, Antel JP, Yong VW, Nuttall RK, Pennington CJ, Edwards DR, Bar-
Or A*. Determinants of human B cell migration across brain endothelial cells. J Immunol 170(9):4497-4505, 2003.
9. Monsonego A, Zota V, Karni A, Krieger JI, Bar-Or A, Bitan G, Budson AE, Sperling R, Selkoe DJ, Weiner HL.
Increased T cell reactivity to amyloid-beta protein in older humans and patients with Alzheimer disease. J Clin
Invest 112(3):415-422, 2003.
10. Antel JP and Bar-Or A. Do myelin antibodies predict the diagnosis of multiple sclerosis? NEJM. 349(2):107-
109;2003.
11. Bar-Or A‡, Nuttall RK‡, Duddy M, Alter A, Kim HJ, Ifergan I, Pennington CJ, Bourgoin P, Edwards DR,Yong VW.
Analyses of all matrix metalloproteinase members in leuckocytes: monocytes as major inflammatory mediators in
Multiple Sclerosis. ‡Co-first authors Brain 126: 2738-2749, 2003.
12. Duddy ME, Alter A, Bar-Or A*. Distinct profiles of human B cell effector cytokines: A role in immune regulation?
J Immunol. 172(6):3422-7, 2004.
13. Kim HJ, Biernacki K, Prat A, Antel JP, Bar-Or A*. Effects of glatiramer acetate-reactive T cells from patients with
multiple sclerosis on human Brain Endothelial Cells: Efficient migration without enhanced inflammation. Clin
Immunol, 111:35-46;2004.
14. Kim HJ, Ifergan I, Antel JP, Seguin R, Duddy M, Lapierre Y, Jalili F, Bar-Or A*. Type-2 monocyte and microglia
differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis. J Immunol. 172: 7144-
7153, 2004.
http://www.neuroinflammation.com/members.asp
MS Presentations
Some of the presentations below require either Macromedia Flash, MS PowerPoint, or Apple Quicktime. You must have the required plugin to use these presentations. Please see the legend below for more details.
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| | The Changing View of MS: Bringing T-Cell and B-Cell Therapies Into Sharper Focus Michael K. Racke, MD - Chair; Amit Bar-Or, MD, FRCP(C); Bruce C. Cree, MD, PhD, MCR; Kathleen S. Hawker, MD | 06/20/06 |
http://www.mscare.org/cmsc/MS-Presentations.html
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