Research News

Gray matter involvement in multiple sclerosis

The authors reviewed the radiological and pathological findings surrounding grey matter involvement in MS, which has traditionally been considered a white matter disease.

authors: Pirko I, Lucchinetti CF, Sriram S, Bakshi R.

source: Neurology. 2007 Feb 27;68(9):634-42

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Tremor in multiple sclerosis

The authors reviewed the most important research on tremor in MS, a very common symptom occurring in 25-60% of MS patients.

authors: Koch M, Mostert J, Heersema D, De Keyser J.

source: J Neurol. 2007 Feb 21

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The patient knows best; significant change in the physical component of the multiple sclerosis impact scale (MSIS-29 physical).

The authors evaluated the reliability of a recently introduced scale for assessment of disability in people with MS, finding it to be useful over time and suitable for use in clinical trials.

authors: Costelloe L, O'rourke K, Kearney H, McGuigan C, Gribbin L, Duggan M, Tubridy N, Daly L, Hutchinson M.

source: J Neurol Neurosurg Psychiatry. 2007 Mar 1

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Cognitive function in relapsing multiple sclerosis: Minimal changes in a 10-year clinical trial

The authors studied the cognitive performance of patients with relapsing MS over 10 years. Interestingly, they did not find any significant cognitive deterioration in these patients.

authors: Schwid SR, Goodman AD, Weinstein A, McDermott MP, Johnson KP; for the Copaxone Study Group.

source: J Neurol Sci. 2007 Feb 27

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Cannabinoid CB1 and CB2 receptors and fatty acid amide hydrolase are specific markers of plaque cell subtypes in human multiple sclerosis

This study on brain tissue samples found that cannabinoid receptors may play a role in the development of multiple sclerosis as they were found to be widely present within the areas of demyelination.

authors: Benito C, Romero JP, Tolon RM, Clemente D, Docagne F, Hillard CJ, Guaza C, Romero J.

source: J Neurosci. 2007 Feb 28;27(9):2396-402.

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